White spot syndrome virus has been the focus of this Centre for a decade. We could demonstrate WSSV in various tissues and organs of Fenneropenaeus indicus by histopathology; develop polyclonal antisera for immunodiagnostics, and a cocktail vaccine to protect shrimp from WSSV. Besides, the carrier/reservoir status of the aquatic animals associated with shrimp culture systems, environmental factors and seasonality favouring the outbreak of WSSV and secondary pathogens associated with the viral infection are also studied. Presently, research is underway to isolate and identify anti-white spot syndrome virus molecules and to elucidate the immunological response of shrimp and to develop a comprehensive WSSV management.